Interleukin-22, a [T.sub.H]17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Article Abstract:
Interleukin-22 (IL-22) belonging to the IL-10 family of cytokines is produced by IL-23-driven T helper cells ([T.sub.H]17 cells). The results have indicated that [T.sub.H]17 cells have necessary functions in host defense and in the pathogenesis of autoimmune diseases such as psoriasis and IL-22 have mediated the crosstalk between the immune system and epithelial cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis
Article Abstract:
The synthesis and biochemical characterization of histone demethylase JHDM2A are explained. The compound is found to be extremely important in controlling the expression of transition nuclear protein 1 (Tnp1) and protamine 1 (Prm1) transcription and spermatogenesis is explained.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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ERM is required from transcriptional control of the spermatogonial stem cell niche
Article Abstract:
The division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo a process of differentiation to form mature sperm. This identifies a new function for family transcription factors in spermatogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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